The case for a PFAS-free future: the link between forever chemicals and cancer

25 May 2025

The Association of European Cancer Leagues (ECL) has released a new position paper urging EU policymakers to take swift action against PFAS chemicals, due to the growing scientific evidence linking these ‘forever chemicals’ to cancer.  

Per- and polyfluoroalkyl substances (PFAS) are a large group of approximately 10,000 human-made chemicals that are used for their non-stick and water-resistant properties. PFAS are found in countless consumer goods and industrial applications, including non-stick cookware, water-repellent fabrics like raincoats, electronics, medicines and medical devices.   

Because PFAS are so widespread, avoiding exposure is nearly impossible. They can take up to 1,000 years to break down, which is why PFAS are often dubbed ‘forever chemicals’. 

Cancer and PFAS: a growing concern 

The scientific evidence linking exposure to PFAS to increased risks of cancer is concerning. While research into the exact number of PFAS chemicals associated with cancer is still ongoing, various studies have established associations between PFAS and cancer: 

  • The World Health Organization’s International Agency for Research on Cancer (IARC) has classified two members of the wider PFAS chemical family – PFOA and PFOS – as proven and possible human carcinogen, respectively.  
  • In a proposal for an EU-wide PFAS ban, the Netherlands, Germany, Denmark, Norway, and Sweden cite elevated risks of kidney cancer and testicular cancer. The proposal identifies 99 PFAS chemicals currently available on the EU market as carcinogenic.  

Beyond cancer, PFAS exposure has been associated with other serious health effects, including liver toxicity, increased cholesterol levels, and reduced vaccine responses in children. Although studies on the possible impact of PFAS on HPV-antibody levels is lacking, findings from other vaccine studies do raise concerns. 

“The scientific evidence linking PFAS to cancer warrants immediate and thorough regulatory action at the EU level. We must act now to prevent cancer and protect future generations,” said Tom Buis, Strategic Policy Advisor at the Dutch Cancer Society and lead author of the position paper.  

EU-wide action is essential 

PFAS pollution is now widespread, with recent figures showing that nearly 23,000 sites all over Europe are contaminated. The annual health costs related to PFAS exposure is estimated to cost Europe between 52 to 84 billion Euros each year. 

The scientific verdict is clear, and the time to act is now. Recognising the threats PFAS pose to public health and the environment, five European countries – the Netherlands, Germany, Denmark, Norway, and Sweden – have jointly submitted a proposal for an EU-wide PFAS restriction.  

As the Association of European Cancer Leagues (ECL), we support this initiative. Prevention is one of the most effective tools we have to reduce the burden of cancer on our society and healthcare systems. Limiting PFAS exposure is a critical step in that fight. 

We call on EU- and national policymakers to: 

  • Adopt a group-based approach to the PFAS restriction, prioritising cancer prevention, public health, and the precautionary principle. 
  • Commit to a PFAS-free future that goes beyond the scope of the EU’s flagship chemicals legislation, REACH.  
  • Limit derogations and ensure all exemptions are strictly timebound.  

Click here to read our position paper 

About the author

Leave a Reply